Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab107795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 4
    • 5-trisphosphate receptor
    • 5-trisphosphate receptor type 1
    • DKFZp313E1334
    • DKFZp313N1434
    • Inositol 1
    • inositol 1 4 5 triphosphate receptor type 1
    • Inositol 1 4 5 trisphosphate Receptor Type 1
    • InsP3R1
    • IP3
    • IP3 receptor
    • IP3 receptor isoform 1
    • IP3R
    • IP3R 1
    • IP3R1
    • ITPR 1
    • Itpr1
    • ITPR1_HUMAN
    • SCA15
    • SCA16
    • SCA29
    • Type 1 inositol 1
    • Type 1 inositol 1 4 5 trisphosphate receptor
    • Type 1 InsP3 receptor
    see all
  • FunctionIntracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • Sequence similaritiesBelongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt

References for IP3 receptor peptide (ab107795)

ab107795 has not yet been referenced specifically in any publications.

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