Anti-IP3 receptor (phospho S1598) antibody (ab111615)

Overview

  • Product nameAnti-IP3 receptor (phospho S1598) antibody
    See all IP3 receptor primary antibodies
  • Description
    Rabbit polyclonal to IP3 receptor (phospho S1598)
  • Specificityab111615 detects endogenous levels of TPR1 only when phosphorylated at serine 1598(human)/1588(mouse).
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from Human ITPR1 around the phosphorylation site of serine 1598/1588 (R-D-SP-V-L).

  • Positive control
    • A549 cells; Human cervix carcinoma tissue.
  • General notes

    This antibody showed negative results in Western Blot

Properties

Applications

Our Abpromise guarantee covers the use of ab111615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

Target

  • FunctionIntracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • Sequence similaritiesBelongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • 5-trisphosphate receptor type 1 antibody
    • DKFZp313E1334 antibody
    • DKFZp313N1434 antibody
    • inositol 1 4 5 triphosphate receptor type 1 antibody
    • Inositol 1 4 5 trisphosphate Receptor Type 1 antibody
    • Inositol 1 antibody
    • InsP3R1 antibody
    • IP3 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 1 antibody
    • IP3R 1 antibody
    • IP3R antibody
    • IP3R1 antibody
    • ITPR 1 antibody
    • Itpr1 antibody
    • ITPR1_HUMAN antibody
    • SCA15 antibody
    • SCA16 antibody
    • SCA29 antibody
    • Type 1 inositol 1 4 5 trisphosphate receptor antibody
    • Type 1 inositol 1 antibody
    • Type 1 InsP3 receptor antibody
    see all

Anti-IP3 receptor (phospho S1598) antibody images

  • ab111615 at 1/100 dilution staining ITPR1 in A549 cells by Immunofluorescence. The picture on the right is treated with the synthesized phosphopeptide.
  • ab111615 at 1/50 dilution staining ITPR1 in paraffin-embedded Human Cervix tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

References for Anti-IP3 receptor (phospho S1598) antibody (ab111615)

ab111615 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111615.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"