Overview

  • Product name
  • Description
    Rabbit polyclonal to IP3KC
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 262-488 of Human IP3KC. (Uniprot:Q96DU7)

  • Positive control
    • Raji whole cell lysate
  • General notes
    Store as concentrated solution

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126146 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 75 kDa.

Target

  • Function
    Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
  • Tissue specificity
    Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.
  • Involvement in disease
    Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.
  • Sequence similarities
    Belongs to the inositol phosphokinase (IPK) family.
  • Cellular localization
    Nucleus. Cytoplasm. Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4 antibody
    • 5-trisphosphate 3-kinase C antibody
    • Inositol 1 antibody
    • inositol 1,4,5 trisphosphate 3 kinase C antibody
    • Inositol trisphosphate 3 kinase C antibody
    • Inositol-trisphosphate 3-kinase C antibody
    • InsP 3 kinase C antibody
    • InsP 3-kinase C antibody
    • IP3 3-kinase C antibody
    • IP3 3KC antibody
    • IP3K C antibody
    • IP3KC antibody
    • IP3KC_HUMAN antibody
    • Itpkc antibody
    see all

Images

  • Anti-IP3KC antibody (ab126146) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 75 kDa

References

ab126146 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


I can confirm that the anti-IP3KC antibody (ab126146) has been raised against a recombinantly expressed fragment of the Human IP3KC protein. This covers the region 262-488 of the protein (Uniprot:Q96DU7). This shares 79% homology with the mouse pr...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up