Overview

  • Product name
    Anti-IP6 Kinase antibody
  • Description
    Rabbit polyclonal to IP6 Kinase
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Rabbit, Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Human IP6 Kinase aa 216-233.
    Sequence:

    PCVLDLKMGTRQHGDDAS


    (Peptide available as ab5007)

  • Positive control
    • WB: rat brain extract.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Primary antibody notes
    Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters and, upon binding to the IP3 receptor (IP3R), triggers the release of intracellular, luminal calcium to the cytosol. Several additional cellular forms of inositol phosphates have been discovered. These include some which have been recently discovered and characterized to possess up to seven or eight phosphate groups, including pyrophosphates (PP-IPs: pyrophosphate-inositol phosphates). It has been proposed that high-energy pyrophosphates may participate in protein phosphorylation. Inositol Hexakisphosphate (IP6) Kinase, or PiUS (Pi Uptake Stimulator) has ATP synthase activity and transfers a phosphate from PP-IP5 to ADP to form ATP thus suggesting an important physiological role for PP-IP5 and IP6 kinase.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab3524 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 46 kDa).Can be blocked with IP6 Kinase peptide (ab5007).

This antibody detects an ~50 kDa protein representing IP6 kinase from rat brain extract.

Target

  • Relevance
    Inositol phosphokinase (IPK) family are responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
  • Cellular localization
    Cytoplasmic
  • Database links
  • Alternative names
    • ATP:1D myo inositol hexakisphosphate phosphotransferase antibody
    • IHPK3 antibody
    • Inositol hexakisphosphate kinase 3 antibody
    • Inositol hexaphosphate kinase 3 antibody
    • InsP6 kinase 3 antibody
    • INSP6K3 antibody
    • IP6K3 antibody
    • IP6K3_HUMAN antibody
    see all

Images



  • Predicted band size : 46 kDa

    Western blot detection of IP6 kinase on rat brain extract using ab3524.

     

References

ab3524 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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