Anti-IPL-1/STK13/Aurora C antibody (ab99492)

Overview

  • Product name
    Anti-IPL-1/STK13/Aurora C antibody
    See all IPL-1/STK13/Aurora C primary antibodies
  • Description
    Goat polyclonal to IPL-1/STK13/Aurora C
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    PRAVVQLGKAQP

    by a Cysteine residue linker, corresponding to N terminal amino acids 4-15 of Human IPL-1/STK13/Aurora C (NP_001015878.1)

  • Positive control
    • Human testis lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab99492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 36 kDa.

Target

  • Function
    May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.
  • Tissue specificity
    Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
  • Involvement in disease
    Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization
    Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
  • Information by UniProt
  • Database links
  • Alternative names
    • AURKC antibody
    • AIE 2 antibody
    • Aie1 antibody
    • AIE2 antibody
    • AIK 3 antibody
    • AIK3 antibody
    • ARK 3 antibody
    • ARK-3 antibody
    • ARK3 antibody
    • Aur C antibody
    • AurC antibody
    • Aurkc antibody
    • AURKC_HUMAN antibody
    • aurora 3 antibody
    • Aurora C antibody
    • Aurora kinase C antibody
    • aurora related kinase 3 antibody
    • Aurora-related kinase 3 antibody
    • Aurora/Ipl1 related kinase 3 antibody
    • Aurora/Ipl1-related kinase 3 antibody
    • Aurora/Ipl1/Eg2 protein 2 antibody
    • EC 2.7.11.1 antibody
    • Serine threonine protein kinase 13 antibody
    • serine/threonine kinase 13 (aurora/IPL1 like) antibody
    • serine/threonine protein kinase aurora C antibody
    • Serine/threonine-protein kinase 13 antibody
    • Serine/threonine-protein kinase aurora-C antibody
    • SPGF5 antibody
    • STK13 antibody
    see all

Images

  • Anti-IPL-1/STK13/Aurora C antibody (ab99492) at 1.5 µg/ml + Human Testis lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 36 kDa

References

ab99492 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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