Overview

  • Product nameAnti-IRAK4 antibody
    See all IRAK4 primary antibodies
  • Description
    Rabbit polyclonal to IRAK4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Sheep, Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids 38-50 (IKKPSGDDRYNQ) and 120-136 (VAQTHGPCQEKDRTSVM) of mouse IRAK4.

  • Positive control
    • Tested with NIH 3T3 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab13685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 51 kDa.

Target

  • FunctionRequired for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
  • Involvement in diseaseDefects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • IL-1 receptor-associated kinase 4 antibody
    • Interleukin 1 receptor associated kinase 4 mutant form 1 antibody
    • Interleukin-1 receptor-associated kinase 4 antibody
    • Interleukin1 receptor associated kinase 4 antibody
    • IPD1 antibody
    • IRAK 4 antibody
    • IRAK-4 antibody
    • IRAK4 antibody
    • IRAK4 mutated form 1 antibody
    • IRAK4_HUMAN antibody
    • LOC 51135 antibody
    • NY REN 64 antibody
    • NY REN 64 antigen antibody
    • NY-REN-64 antibody
    • REN64 antibody
    • Renal carcinoma antigen NY-REN-64 antibody
    see all

Anti-IRAK4 antibody images

  • Western blot analysis of IRAK-4 in 30 ugs of NIH 3T3 cell lysate using ab13685 at 1:500 dilution.

References for Anti-IRAK4 antibody (ab13685)

This product has been referenced in:
  • Kallapur SG  et al. Pulmonary and Systemic Endotoxin Tolerance in Preterm Fetal Sheep Exposed to Chorioamnionitis. J Immunol 179:8491-8499 (2007). WB ; Sheep . Read more (PubMed: 18056396) »
  • Liu G  et al. Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. J Immunol 179:4125-34 (2007). WB ; Human . Read more (PubMed: 17785851) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab13685.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"