Overview

  • Product nameAnti-IRAKM antibody
    See all IRAKM primary antibodies
  • Description
    Goat polyclonal to IRAKM
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    GHSYGSKPMEKR

    , corresponding to internal sequence amino acids 582-593 of Mouse IRAKM

  • Positive control
    • Rat Liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77394 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/64,000.
    WB: Use at a concentration of 0.05 - 0.2 µg/ml. Detects a band of approximately 67 kDa (predicted molecular weight: 67 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
    • Tissue specificityExpressed predominantly in peripheral blood lymphocytes.
    • Involvement in diseaseDefects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
    • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
      Contains 1 death domain.
      Contains 1 protein kinase domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • ASRT5 antibody
      • IL 1 receptor associated kinase M antibody
      • IL-1 receptor-associated kinase M antibody
      • IL1 receptor associated kinase M antibody
      • Interleukin 1 receptor associated kinase 3 antibody
      • Interleukin 1 receptor associated kinase M antibody
      • Interleukin-1 receptor-associated kinase 3 antibody
      • IRAK M antibody
      • IRAK-3 antibody
      • IRAK-M antibody
      • Irak3 antibody
      • IRAK3_HUMAN antibody
      see all

    Anti-IRAKM antibody images

    • Anti-IRAKM antibody (ab77394) at 0.05 µg/ml + Rat Liver lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 67 kDa
      Observed band size : 67 kDa

    References for Anti-IRAKM antibody (ab77394)

    ab77394 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"