Anti-IRF3 (phospho S386) antibody [EPR2346] (ab76493)

Publishing research using ab76493? Please let us know so that we can cite the reference in this datasheet.

ab76493 has been referenced in 45 publications.

  • Oh C  et al. A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature. Sci Rep 8:84 (2018). PubMed: 29311560
  • He X  et al. ERRa negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction. PLoS Pathog 13:e1006347 (2017). WB ; Human . PubMed: 28591144
  • Hu X  et al. Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-ßthrough Its Deubiquitinase Activity. Biomed Res Int 2017:7089091 (2017). PubMed: 29201911
  • Fang R  et al. MAVS activates TBK1 and IKKe through TRAFs in NEMO dependent and independent manner. PLoS Pathog 13:e1006720 (2017). PubMed: 29125880
  • Rui Y  et al. Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68. J Virol 91:N/A (2017). PubMed: 28424289
  • Agod Z  et al. Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells. Redox Biol 13:633-645 (2017). PubMed: 28818792
  • Mildenberger J  et al. N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy 13:1664-1678 (2017). PubMed: 28820283
  • Chen GA  et al. H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status. Front Immunol 8:972 (2017). PubMed: 28848563
  • Zhang X  et al. GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. PLoS Pathog 13:e1006321 (2017). PubMed: 28394926
  • Pryke KM  et al. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio 8:N/A (2017). PubMed: 28465426
  • Zheng Z  et al. Bacterial E3 Ubiquitin Ligase IpaH4.5 of Shigella flexneri Targets TBK1 To Dampen the Host Antibacterial Response. J Immunol 196:1199-208 (2016). PubMed: 26700764
  • Sanchez David RY  et al. Comparative analysis of viral RNA signatures on different RIG-I-like receptors. Elife 5:e11275 (2016). WB . PubMed: 27011352
  • Huang LY  et al. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS One 11:e0160875 (2016). Human . PubMed: 27504984
  • Tremblay N  et al. Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response. PLoS Pathog 12:e1005772 (2016). WB . PubMed: 27454487
  • Lin TH  et al. Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus. Front Immunol 7:440 (2016). WB ; Human . PubMed: 27826297
  • Pourcelot M  et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. BMC Biol 14:69 (2016). WB ; Human . PubMed: 27538435
  • Kimura T  et al. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J Cell Biol 210:973-89 (2015). PubMed: 26347139
  • Zhang H  et al. Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5:18035 (2015). PubMed: 26669264
  • Chang TH  et al. Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-?B Pathways along with TNFR-Associated Factor 6. J Immunol 195:5367-79 (2015). PubMed: 26503954
  • Chang JT  et al. Genome and infection characteristics of human parechovirus type 1: the interplay between viral infection and type I interferon antiviral system. PLoS One 10:e0116158 (2015). PubMed: 25646764
  • Sali TM  et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog 11:e1005324 (2015). PubMed: 26646986
  • Yuan MM  et al. TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis. BMC Cancer 15:245 (2015). IHC . PubMed: 25884709
  • Miller MS  et al. Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nat Immunol 16:485-94 (2015). PubMed: 25822250
  • Lin L  et al. HSPD1 interacts with IRF3 to facilitate interferon-beta induction. PLoS One 9:e114874 (2014). PubMed: 25506707
  • Peng Y  et al. HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. PLoS Pathog 10:e1004041 (2014). PubMed: 24763515
  • Angleró-Rodríguez YI  et al. Dengue virus subverts the interferon induction pathway via NS2B/3 protease-I?B kinase epsilon interaction. Clin Vaccine Immunol 21:29-38 (2014). PubMed: 24173023
  • Zhou Z  et al. TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. Proc Natl Acad Sci U S A 111:E245-54 (2014). WB . PubMed: 24379373
  • Santiago FW  et al. Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses. J Virol 88:4572-85 (2014). PubMed: 24478431
  • Ichikawa T  et al. TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. J Immunol 192:4977-88 (2014). Human . PubMed: 24760149
  • Xiang Z  et al. Enterovirus 68 3C Protease Cleaves TRIF To Attenuate Antiviral Responses Mediated by Toll-Like Receptor 3. J Virol 88:6650-9 (2014). PubMed: 24672048
  • Muvaffak A  et al. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol Cancer Res 12:1055-66 (2014). PubMed: 24752990
  • Feng J  et al. RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production. J Virol 88:7987-97 (2014). PubMed: 24807708
  • Chugh PE  et al. Toll-like receptor-3 is dispensable for the innate microRNA response to West Nile virus (WNV). PLoS One 9:e104770 (2014). WB ; Human . PubMed: 25127040
  • Charoenthongtrakul S  et al. RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One 8:e53717 (2013). WB . PubMed: 23308279
  • Lu HL & Liao F Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication. J Immunol 191:3264-76 (2013). PubMed: 23926323
  • Gorbea C  et al. Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling. Sci Signal 6:ra86 (2013). PubMed: 24084648
  • Gavala ML  et al. Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-ß production in murine macrophages. J Leukoc Biol 94:759-68 (2013). ICC/IF ; Mouse . PubMed: 23911869
  • Schoggins JW  et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature N/A:N/A (2013). PubMed: 24284630
  • Ma X  et al. Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc Natl Acad Sci U S A 109:9378-83 (2012). WB . PubMed: 22619329
  • Herman M  et al. Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med 209:1567-82 (2012). PubMed: 22851595
  • Fichorova RN  et al. Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. PLoS One 7:e48418 (2012). WB . PubMed: 23144878
  • Liu F  et al. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13:254-62 (2011). PubMed: 21336305
  • Gao L  et al. ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling. J Biol Chem 286:36592-602 (2011). WB . PubMed: 21885437
  • Alam S  et al. Galectin-9 protein expression in endothelial cells is positively regulated by histone deacetylase 3. J Biol Chem 286:44211-7 (2011). WB ; Human . PubMed: 22027828
  • Liu XY  et al. Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Res 20:994-1011 (2010). WB ; Human . PubMed: 20628368


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