Overview

  • Product nameAnti-IRF8 antibody
    See all IRF8 primary antibodies
  • Description
    Goat polyclonal to IRF8
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to amino acids

    QRSFFRENQQITV

    from the C terminal of Human IRF8.

  • Positive control
    • K562 lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab85734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 47 kDa (predicted molecular weight: 47 kDa).
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionSpecifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
  • Tissue specificityPredominantly in lymphoid tissues.
  • Sequence similaritiesBelongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Post-translational
    modifications
    Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • H ICSBP antibody
    • H-ICSBP antibody
    • HGNC:5358 antibody
    • HICSBP antibody
    • ICSBP 1 antibody
    • ICSBP antibody
    • ICSBP1 antibody
    • Interferon consensus sequence binding protein 1 antibody
    • Interferon consensus sequence binding protein antibody
    • Interferon consensus sequence-binding protein antibody
    • Interferon regulatory factor 8 antibody
    • IRF 8 antibody
    • IRF-8 antibody
    • Irf8 antibody
    • IRF8_HUMAN antibody
    • MYLS antibody
    see all

Anti-IRF8 antibody images

  • Anti-IRF8 antibody (ab85734) at 1 µg/ml + K562 lysate at 30 µg

    Predicted band size : 47 kDa
    Observed band size : 47 kDa

References for Anti-IRF8 antibody (ab85734)

ab85734 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"