Rabbit monoclonal [EPR12124] to Iroquois homeobox protein 3
Flow Cyt, WBmore details Unsuitable for:
ICC,IHC-P or IP
Mouse, Rat, Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Iroquois homeobox protein 3 aa 50-150 (Cysteine residue). The exact sequence is proprietary. Database link: P78415
Hela, Jurkat, A431 and K562 cell lysates; K562 cells.
This product is a recombinant rabbit monoclonal antibody.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells.
Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain.
Singh B et al. Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge. PLoS One11:e0159072 (2016).
Read more (PubMed: 27390851) »
Landgraf K et al. FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children? PLoS One11:e0161739 (2016).
Read more (PubMed: 27560134) »