FunctionMay mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Involvement in diseasePolymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
Post-translational modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor. Phosphorylation of Tyr-896 is required for GRB2-binding.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab58479 at a dilution of 1/50. Right hand image: treated with immunising peptide. Left hand image: untreated.Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab58479 at a dilution of 1/50. Right hand image: treated with immunising peptide. Left hand image: untreated.
References for Anti-IRS1 (phospho S616) antibody (ab58479)
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