Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5224 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Additional notesPositive (ab5224P) and negative (ab5224N) control peptides for the IRS 1 Receptor phospho tyrosine 896 rabbit polyclonal antibody ab4873. Molecular Weight: ab5224P - 1718 ab5224N - 1638 Peptide Content: 80 ± 4% Quantity: 100ug of each peptide.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: Trifluoroacetate salt

General Info

  • Alternative names
    • HIRS 1
    • HIRS1
    • Insulin receptor substrate 1
    • IRS 1
    • IRS-1
    • IRS1
    • IRS1_HUMAN
    • OTTHUMP00000164234
    see all
  • FunctionMay mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • Involvement in diseasePolymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
  • Sequence similaritiesContains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • Post-translational
    modifications
    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt

References for IRS1 (phospho Y896) peptide (ab5224)

ab5224 has not yet been referenced specifically in any publications.

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