Overview

  • Product name
  • Description
    Mouse monoclonal to IRX5
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: PQKPEDKADP EGPEAGGAEQ KAASGCERLQ GPPTPAGKET EGSLSDSDFK EPPSEGRLDA L, corresponding to amino acids 204-265 of Human IRX5

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab56681 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 50 kDa.

Target

  • Function
    Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells.
  • Sequence similarities
    Belongs to the TALE/IRO homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Homeodomain protein IRX-2A antibody
    • Homeodomain protein IRXB2 antibody
    • Iroquois homeobox protein 5 antibody
    • Iroquois-class homeodomain protein IRX-5 antibody
    • IRX2A antibody
    • Irx5 antibody
    • IRX5_HUMAN antibody
    • IRXB2 antibody
    see all

Images



  • Predicted band size : 50 kDa
    IRX5 antibody (ab56681) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

References

This product has been referenced in:
  • Singh B  et al. Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge. PLoS One 11:e0159072 (2016). WB ; Human . Read more (PubMed: 27390851) »
  • Panguluri SK  et al. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. Am J Physiol Heart Circ Physiol 304:H1651-61 (2013). Mouse . Read more (PubMed: 23585127) »

See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab56681.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up