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Rabbit polyclonal to Isocitrate dehydrogenase
Predicted to work with:
Mouse, Rat, Cow, Zebrafish
Recombinant Human Isocitrate dehydrogenase protein.
Human liver and prostate tissues; A431 and Raji whole cell lysates
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: Tris glycine, 10% Glycerol
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
Use a concentration of 10 µg/ml.
Involvement in disease
Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Acetylation at Lys-374 dramatically reduces catalytic activity.
Information by UniProt
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"