Anti-Isocitrate dehydrogenase antibody (ab116609)

Overview

  • Product name
    Anti-Isocitrate dehydrogenase antibody
    See all Isocitrate dehydrogenase primary antibodies
  • Description
    Goat polyclonal to Isocitrate dehydrogenase
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Saccharomyces cerevisiae
  • Immunogen

    Synthetic peptide:

    EPGSRHVGLDIKGQN

    with a Cysteine residue linker, corresponding to internal sequence amino acids 281-295 of Saccharomyces cerevisiae Isocitrate dehydrogenase (NP_014361).

  • Positive control
    • S. cerevisiae lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab116609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 39 kDa.

Target

  • Involvement in disease
    Glioma
    Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
  • Sequence similarities
    Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  • Post-translational
    modifications
    Acetylation at Lys-374 dramatically reduces catalytic activity.
  • Cellular localization
    Cytoplasm. Peroxisome.
  • Information by UniProt
  • Database links
    • Alternative names
      • Cytosolic NADP isocitrate dehydrogenase antibody
      • Cytosolic NADP-isocitrate dehydrogenase antibody
      • Epididymis luminal protein 216 antibody
      • Epididymis secretory protein Li 26 antibody
      • HEL-216 antibody
      • HEL-S-26 antibody
      • ICDH antibody
      • IDCD antibody
      • IDH antibody
      • IDH1 antibody
      • IDHC_HUMAN antibody
      • IDP antibody
      • IDPC antibody
      • Isocitrate dehydrogenase (NADP(+)) 1 cytosolic antibody
      • Isocitrate dehydrogenase [NADP] cytoplasmic antibody
      • Isocitrate dehydrogenase 1 (NADP+) soluble antibody
      • NADP dependent isocitrate dehydrogenase cytosolic antibody
      • NADP dependent isocitrate dehydrogenase peroxisomal antibody
      • NADP(+)-specific ICDH antibody
      • Oxalosuccinate decarboxylase antibody
      • PICD antibody
      see all

    Images

    • All lanes : Anti-Isocitrate dehydrogenase antibody (ab116609) at 0.5 µg/ml

      Lane 1 : S. cerevisae isocitrate dehydrogenase knock-out mutant lysate
      Lane 2 : S. cerevisae isocitrate dehydrogenase wildtype lysate

      Lysates/proteins at 35 µg per lane.

      Developed using the ECL technique

      Predicted band size : 39 kDa

    References

    ab116609 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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