Anti-Isocitrate dehydrogenase antibody (ab117539)

Overview

  • Product name
    Anti-Isocitrate dehydrogenase antibody
    See all Isocitrate dehydrogenase primary antibodies
  • Description
    Rabbit polyclonal to Isocitrate dehydrogenase
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to C terminal residues of Human Isocitrate dehydrogenase (NP_005887.2).

  • Positive control
    • Human adrenal, liver and uterus tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab117539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Involvement in disease
    Glioma
    Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
  • Sequence similarities
    Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  • Post-translational
    modifications
    Acetylation at Lys-374 dramatically reduces catalytic activity.
  • Cellular localization
    Cytoplasm. Peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytosolic NADP isocitrate dehydrogenase antibody
    • Cytosolic NADP-isocitrate dehydrogenase antibody
    • Epididymis luminal protein 216 antibody
    • Epididymis secretory protein Li 26 antibody
    • HEL-216 antibody
    • HEL-S-26 antibody
    • ICDH antibody
    • IDCD antibody
    • IDH antibody
    • IDH1 antibody
    • IDHC_HUMAN antibody
    • IDP antibody
    • IDPC antibody
    • Isocitrate dehydrogenase (NADP(+)) 1 cytosolic antibody
    • Isocitrate dehydrogenase [NADP] cytoplasmic antibody
    • Isocitrate dehydrogenase 1 (NADP+) soluble antibody
    • NADP dependent isocitrate dehydrogenase cytosolic antibody
    • NADP dependent isocitrate dehydrogenase peroxisomal antibody
    • NADP(+)-specific ICDH antibody
    • Oxalosuccinate decarboxylase antibody
    • PICD antibody
    see all

Images

  • ab117539, at 5 µg/ml, staining Isocitrate dehydrogenase in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.
  • ab117539, at 5 µg/ml, staining Isocitrate dehydrogenase in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.
  • ab117539, at 5 µg/ml, staining Isocitrate dehydrogenase in Formalin-fixed, Paraffin-embedded Human Uterus tissue by Immunohistochemistry.

References

ab117539 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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