Anti-Isocitrate dehydrogenase antibody (ab36329)

Overview

  • Product nameAnti-Isocitrate dehydrogenase antibody
    See all Isocitrate dehydrogenase primary antibodies
  • Description
    Rabbit polyclonal to Isocitrate dehydrogenase
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Full length native protein purified from porcine heart

  • Positive control
    • WB: mouse tissues including spleen, kidney, lung, heart, liver and brain.

Properties

Applications

Our Abpromise guarantee covers the use of ab36329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/400 - 1/1600.
WB 1/500 - 1/2000. Detects a band of approximately 40 kDa (predicted molecular weight: 47 kDa).

Target

  • Involvement in diseaseGlioma
    Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
  • Sequence similaritiesBelongs to the isocitrate and isopropylmalate dehydrogenases family.
  • Post-translational
    modifications
    Acetylation at Lys-374 dramatically reduces catalytic activity.
  • Cellular localizationCytoplasm. Peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytosolic NADP isocitrate dehydrogenase antibody
    • Cytosolic NADP-isocitrate dehydrogenase antibody
    • Epididymis luminal protein 216 antibody
    • Epididymis secretory protein Li 26 antibody
    • HEL-216 antibody
    • HEL-S-26 antibody
    • ICDH antibody
    • IDCD antibody
    • IDH antibody
    • IDH1 antibody
    • IDHC_HUMAN antibody
    • IDP antibody
    • IDPC antibody
    • Isocitrate dehydrogenase [NADP] cytoplasmic antibody
    • Isocitrate dehydrogenase 1 (NADP+) soluble antibody
    • NADP dependent isocitrate dehydrogenase cytosolic antibody
    • NADP dependent isocitrate dehydrogenase peroxisomal antibody
    • NADP(+)-specific ICDH antibody
    • Oxalosuccinate decarboxylase antibody
    • PICD antibody
    see all

Anti-Isocitrate dehydrogenase antibody images

  • Titration curve of ab36329, rabbit antibody to Isocitrate dehyrogenase (ICDH). Plates coated with 400 ng/well of native Isocitrate Dedydrogenease derived from pig heart.

References for Anti-Isocitrate dehydrogenase antibody (ab36329)

This product has been referenced in:
  • Bellingham M  et al. Exposure to chemical cocktails before or after conception - the effect of timing on ovarian development. Mol Cell Endocrinol 376:156-72 (2013). IHC . Read more (PubMed: 23791816) »
  • Mancone C  et al. Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes. J Hepatol 52:234-43 (2010). WB ; Mouse . Read more (PubMed: 20031246) »

See all 5 Publications for this product

Product Wall

Thank you for your enquiry. I have conferred with out laboratory and it seems that we have not tested the cross reactivity with all isoforms of the antibody, so unfortunately we do not know if ab36329 is Isocitrate dehydrogenase I or not. I am...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"