Rabbit monoclonal [EPR12297(B)] to Isocitrate dehydrogenase
WBmore details Unsuitable for:
Flow Cyt,ICC/IF,IHC-P or IP
Mouse, Rat, Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Isocitrate dehydrogenase aa 350 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: O75874
HeLa and HepG2 cell lysates.
This product is a recombinant rabbit monoclonal antibody.
Produced under U.S. Patent No. 5,675,063.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Glioma Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Acetylation at Lys-374 dramatically reduces catalytic activity.