Overview

  • Product nameAnti-ITGA8 antibody
    See all ITGA8 primary antibodies
  • Description
    Mouse monoclonal to ITGA8
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment: SDTILEVGWP FSARDEFLLY IFHIQTLGPL QCQPNPNINP QDIKPAASPE DTPELSAFLR NSTIPHLVRK RDVHVVEFHR QSPAKILNCT NIECLQISCA , corresponding to amino acids 836-936 of Human ITGA8

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab56355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
IHC-P Use at an assay dependent concentration. PubMed: 20435685

Target

  • FunctionIntegrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
  • Tissue specificityExpressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Integrin alpha 8 antibody
    • Integrin alpha-8 heavy chain antibody
    • Integrin alpha-8 light chain antibody
    • ITA8_HUMAN antibody
    • ITGA 8 antibody
    • ITGA8 antibody
    see all

Anti-ITGA8 antibody images

  • Western blot against tagged recombinant protein immunogen using ab56355 ITGA8 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

References for Anti-ITGA8 antibody (ab56355)

This product has been referenced in:
  • Singh SR  et al. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? Am J Physiol Lung Cell Mol Physiol 299:L169-83 (2010). IHC-P ; Human . Read more (PubMed: 20435685) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"