Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human kidney tissue, labeling ITGA8 using ab170464 at a 1/50 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot - Anti-ITGA8 antibody - C-terminal (ab170464)
Anti-ITGA8 antibody - C-terminal (ab170464) at 1/100 dilution + K562 cell lysate at 35 µg