Overview

  • Product nameAnti-ITGB3BP antibody
    See all ITGB3BP primary antibodies
  • Description
    Mouse monoclonal to ITGB3BP
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MSLFASPTSS EEQKHRNGLS NEKRKKLNHP SLTESKESTT KDNDEFMMLL SKVEKLSEEI MEIMQNLSSI QALEGSRELE NLIGISCASH FLKREMQKTK , corresponding to amino acids 1-100 of Human ITGB3BP

Applications

Our Abpromise guarantee covers the use of ab57098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceITGB3BP is a transcriptional coregulator that has both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP also acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit. ITGB3BP induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization. It also acts as a component of the CENPH-CENPI centromeric complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
    • Cellular localizationIsoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Cytoplasm. Note=Localizes in the centromeres. Isoform 3 is predominantly nuclear and weakly cytoplasmic.
    • Database links
    • Alternative names
      • Beta 3 endonexin antibody
      • Beta3 endonexin antibody
      • Beta3 endonexin long form antibody
      • CENP R antibody
      • CENPR antibody
      • CENPR_HUMAN antibody
      • Centromere protein R antibody
      • endonexin, Beta-3 antibody
      • HSU37139 antibody
      • Integrin beta 3 binding protein (beta3-endonexin) antibody
      • Integrin beta 3 binding protein antibody
      • NRIF 3 antibody
      • NRIF3 antibody
      • Nuclear receptor interacting factor 3 antibody
      • TAP 20 antibody
      • TAP20 antibody
      see all

    Anti-ITGB3BP antibody images



    • Predicted band size : 20 kDa
      ITGB3BP antibody (ab57098) at 1ug/lane + A-431 cell lysate at 25ug/lane.

    References for Anti-ITGB3BP antibody (ab57098)

    ab57098 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57098.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"