The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 104 kDa). (Rat samples)
FunctionMay be involved in acute phase reactions.
Tissue specificityLiver specific.
Sequence similaritiesBelongs to the ITIH family. Contains 1 VIT domain. Contains 1 VWFA domain.
Post-translational modificationsCleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. Appears to be both N- and O-glycosylated. The O-linked polysaccharides on Ser-696, Thr-701 and Ser-702 are probably the mucin type linked to GalNAc.