Overview

  • Product name
  • Description
    Goat polyclonal to ITK
  • Host species
    Goat
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Monkey, Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide corresponding to Human ITK aa 596-607 (Cysteine residue).
    Sequence:

    KERPEDRPAFSR


    Database link: Q08881

  • Positive control
    • Human spleen tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99% Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab189388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Plays a role in T-cell proliferation and differentiation.
  • Tissue specificity
    T-cell lines and natural killer cell lines.
  • Involvement in disease
    Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1) [MIM:613011]. LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
    Contains 1 Btk-type zinc finger.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Cellular localization
    Cell membrane. Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • EMT antibody
    • Homolog of mouse T cell itk/tsk antibody
    • IL 2 inducible T cell kinase antibody
    • IL2 inducible T cell kinase antibody
    • Interleukin 2 inducible T cell kinase antibody
    • Itk antibody
    • ITK_HUMAN antibody
    • Kinase EMT antibody
    • LPFS1 antibody
    • LYK antibody
    • MGC126257 antibody
    • MGC126258 antibody
    • PSCTK 2 antibody
    • PSCTK2 antibody
    • T cell specific kinase antibody
    • T-cell-specific kinase antibody
    • TSK antibody
    • Tyrosine protein kinase antibody
    • Tyrosine protein kinase ITK/TSK antibody
    • Tyrosine protein kinase Lyk antibody
    • Tyrosine-protein kinase ITK/TSK antibody
    • Tyrosine-protein kinase Lyk antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human spleen tissue sections labeling ITK using ab189388 at 3.75 µg/ml.

References

ab189388 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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