Overview

  • Product nameAnti-ITM2B antibody
    See all ITM2B primary antibodies
  • Description
    Rabbit polyclonal to ITM2B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 65 and 234 of Human ITM2B (AAH00554)

  • Positive control
    • A549 and HeLa cell lines. HepG2 or HCT116 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab101522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 30 kDa.

Target

  • FunctionFunctions as a protease inhibitor. Plays a role in APP processing regulating the physiological production of the beta amyloid peptide. Restricts docking of gamma-secretase to APP and access of alpha- and beta-secretase to their cleavage APP sequence.
  • Tissue specificityExpressed in brain and in other tissues.
  • Involvement in diseaseDefects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) [MIM:176500]. A disorder characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. Clinical features include progressive mental deterioration, spasticity and muscular rigidity.
    Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) [MIM:117300]; also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. Plaques and neurofibrillary tangles are observed in the hippocampus. Clinical features include progressive ataxia, dementia, cataracts and deafness.
  • Sequence similaritiesBelongs to the ITM2 family.
    Contains 1 BRICHOS domain.
  • Post-translational
    modifications
    The C-terminal part of the ectodomain is processed by furin and related proteases producing a secreted peptide of 4 to 5 kDa. For the ABRI and ADAN variants the C-terminal secreted peptide is larger and may produce amyloid fibrils responsible for neuronal dysfunction and dementia. The remaining part of the ectodomain containing the BRICHOS domain is cleaved by ADAM10 and is secreted as a peptide of 25 kDa. The membrane-bound N-terminal fragment (NTF) of 22 kDa is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted peptide (BRI2C) and an intracellular domain (ICD) released in the cytosol.
  • Cellular localizationGolgi apparatus membrane. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ABRI antibody
    • ABri/ADan amyloid peptide antibody
    • BRI 2 antibody
    • BRI antibody
    • BRI2 antibody
    • BRICD 2B antibody
    • BRICD2B antibody
    • BRICHOS domain containing 2B antibody
    • E25B antibody
    • E3 16 antibody
    • E3-16 antibody
    • FBD antibody
    • Integral membrane protein 2B antibody
    • ITM 2B antibody
    • ITM2B antibody
    • ITM2B_HUMAN antibody
    • Protein E25B antibody
    • Transmembrane protein BRI antibody
    see all

Anti-ITM2B antibody images

  • All lanes : Anti-ITM2B antibody (ab101522) at 1/1000 dilution

    Lane 1 : HepG2 whole cell lysate
    Lane 2 : HCT116 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 30 kDa

References for Anti-ITM2B antibody (ab101522)

ab101522 has not yet been referenced specifically in any publications.

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