• Product nameAnti-ITM2B antibody
    See all ITM2B primary antibodies
  • Description
    Goat polyclonal to ITM2B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 224-238 of Human ITM2B (NP_068839.1).

  • Positive control
    • Human Hippocampus lysate



Our Abpromise guarantee covers the use of ab92284 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 30 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions as a protease inhibitor. Plays a role in APP processing regulating the physiological production of the beta amyloid peptide. Restricts docking of gamma-secretase to APP and access of alpha- and beta-secretase to their cleavage APP sequence.
    • Tissue specificityExpressed in brain and in other tissues.
    • Involvement in diseaseDefects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) [MIM:176500]. A disorder characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. Clinical features include progressive mental deterioration, spasticity and muscular rigidity.
      Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) [MIM:117300]; also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. Plaques and neurofibrillary tangles are observed in the hippocampus. Clinical features include progressive ataxia, dementia, cataracts and deafness.
    • Sequence similaritiesBelongs to the ITM2 family.
      Contains 1 BRICHOS domain.
    • Post-translational
      The C-terminal part of the ectodomain is processed by furin and related proteases producing a secreted peptide of 4 to 5 kDa. For the ABRI and ADAN variants the C-terminal secreted peptide is larger and may produce amyloid fibrils responsible for neuronal dysfunction and dementia. The remaining part of the ectodomain containing the BRICHOS domain is cleaved by ADAM10 and is secreted as a peptide of 25 kDa. The membrane-bound N-terminal fragment (NTF) of 22 kDa is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted peptide (BRI2C) and an intracellular domain (ICD) released in the cytosol.
    • Cellular localizationGolgi apparatus membrane. Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ABRI antibody
      • ABri/ADan amyloid peptide antibody
      • BRI 2 antibody
      • BRI antibody
      • BRI2 antibody
      • BRICD 2B antibody
      • BRICD2B antibody
      • BRICHOS domain containing 2B antibody
      • E25B antibody
      • E3 16 antibody
      • E3-16 antibody
      • FBD antibody
      • Integral membrane protein 2B antibody
      • ITM 2B antibody
      • ITM2B antibody
      • ITM2B_HUMAN antibody
      • Protein E25B antibody
      • Transmembrane protein BRI antibody
      see all

    Anti-ITM2B antibody images

    • Anti-ITM2B antibody (ab92284) at 1 µg/ml + Human Hippocampus lysate at 35 µg
      developed using the ECL technique

      Predicted band size : 30 kDa
      Observed band size : 30 kDa

    References for Anti-ITM2B antibody (ab92284)

    ab92284 has not yet been referenced specifically in any publications.

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