Overview

  • Product nameAnti-ITM2C antibody
    See all ITM2C primary antibodies
  • Description
    Rabbit polyclonal to ITM2C
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 101-150 (EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR) of Human ITM2C (NP_112188).

  • Positive control
    • Jurkat cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferConstituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab118723 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionNegative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
  • Tissue specificityHigh levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
  • Sequence similaritiesBelongs to the ITM2 family.
    Contains 1 BRICHOS domain.
  • Post-translational
    modifications
    Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C.
  • Cellular localizationLysosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BRI3 antibody
    • BRICD2C antibody
    • BRICHOS domain containing 2C antibody
    • Cerebral protein 14 antibody
    • CT-BRI3 antibody
    • E25 antibody
    • E25C antibody
    • Integral membrane protein 2C antibody
    • Integral membrane protein 3 antibody
    • Itm2c antibody
    • ITM2C_HUMAN antibody
    • ITM3 antibody
    • NPD018 antibody
    • Transmembrane protein BRI3 antibody
    see all

Anti-ITM2C antibody images

  • Anti-ITM2C antibody (ab118723) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 30 kDa

References for Anti-ITM2C antibody (ab118723)

ab118723 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"