Overview

  • Product nameAnti-ITPR2 antibody
    See all ITPR2 primary antibodies
  • Description
    Goat polyclonal to ITPR2
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Synthetic peptide:

    C-PIEESNILSPVQD

    , corresponding to internal sequence amino acids 1152-1164 of Human ITPR2.

  • Positive control
    • Human heart, skin and kidney tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab104550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/128000.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • Tissue specificityIsoform Short is found in skeletal muscle and heart.
  • Involvement in diseaseAnhidrosis, isolated, with normal sweat glands
  • Sequence similaritiesBelongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • Inositol 1 4 5 trisphosphate receptor type 2 antibody
    • Inositol 1,4,5-trisphosphate receptor type 2 antibody
    • Inositol 145 trisphosphate receptor type 2 antibody
    • InsP3 R2 antibody
    • InsP3R2 antibody
    • IP3 R2 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 2 antibody
    • IP3R 2 antibody
    • IP3R2 antibody
    • ITPR 2 antibody
    • Itpr2 antibody
    • ITPR2_HUMAN antibody
    • Type 2 inositol 1 4 5 trisphosphate receptor antibody
    • Type 2 inositol 1 antibody
    • Type 2 inositol 145 trisphosphate receptor antibody
    • Type 2 InsP3 receptor antibody
    see all

Anti-ITPR2 antibody images

  • ab104550 at 3.75µg/ml staining ITPR2 in Human heart by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab104550 at 3.75µg/ml staining ITPR2 in Human skin by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab104550 at 3.75µg/ml staining ITPR2 in Human kidney by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-ITPR2 antibody (ab104550)

ab104550 has not yet been referenced specifically in any publications.

Product Wall

DISCOUNT CODE: 100%ABR-0000

Ablaufdatum: 01 Februar 2013

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"