Overview

  • Product nameAnti-ITPR2 antibody
    See all ITPR2 primary antibodies
  • Description
    Rabbit polyclonal to ITPR2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (Human) from a C terminal sequence.

Properties

Applications

Our Abpromise guarantee covers the use of ab55981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 308 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • Tissue specificityIsoform Short is found in skeletal muscle and heart.
  • Involvement in diseaseAnhidrosis, isolated, with normal sweat glands
  • Sequence similaritiesBelongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • Inositol 1 4 5 trisphosphate receptor type 2 antibody
    • Inositol 1,4,5-trisphosphate receptor type 2 antibody
    • Inositol 145 trisphosphate receptor type 2 antibody
    • InsP3 R2 antibody
    • InsP3R2 antibody
    • IP3 R2 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 2 antibody
    • IP3R 2 antibody
    • IP3R2 antibody
    • ITPR 2 antibody
    • Itpr2 antibody
    • ITPR2_HUMAN antibody
    • Type 2 inositol 1 4 5 trisphosphate receptor antibody
    • Type 2 inositol 1 antibody
    • Type 2 inositol 145 trisphosphate receptor antibody
    • Type 2 InsP3 receptor antibody
    see all

References for Anti-ITPR2 antibody (ab55981)

ab55981 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"