The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 22285480
Is unsuitable for WB.
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Isoform Short is found in skeletal muscle and heart.
Involvement in disease
Anhidrosis, isolated, with normal sweat glands
Belongs to the InsP3 receptor family. Contains 5 MIR domains.
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Okamoto Y et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol52:988-97 (2012).
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