Overview

  • Product nameAnti-ITPR2 antibody
    See all ITPR2 primary antibodies
  • Description
    Rabbit polyclonal to ITPR2
  • Tested applicationsSuitable for: ICC, IHC-Fr, ICC/IFmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Mouse, Rat, Human, Amphibians, Salamander
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide corresponding to Rat ITPR2 aa 317-334.
    Sequence:

    ELNPDYRDAQNEGKTVRD


    (Peptide available as ab5842)

  • Positive control
    • Rat brain staining of the hippocampus, corpus collosum, and cerebellum.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab5805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC 1/100.
IHC-Fr 1/100.
ICC/IF Use at an assay dependent concentration. PubMed: 22285480
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
    • Tissue specificityIsoform Short is found in skeletal muscle and heart.
    • Involvement in diseaseAnhidrosis, isolated, with normal sweat glands
    • Sequence similaritiesBelongs to the InsP3 receptor family.
      Contains 5 MIR domains.
    • DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
    • Post-translational
      modifications
      Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
    • Cellular localizationEndoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4 antibody
      • 5-trisphosphate receptor antibody
      • Inositol 1 4 5 trisphosphate receptor type 2 antibody
      • Inositol 1,4,5-trisphosphate receptor type 2 antibody
      • Inositol 145 trisphosphate receptor type 2 antibody
      • InsP3 R2 antibody
      • InsP3R2 antibody
      • IP3 R2 antibody
      • IP3 receptor antibody
      • IP3 receptor isoform 2 antibody
      • IP3R 2 antibody
      • IP3R2 antibody
      • ITPR 2 antibody
      • Itpr2 antibody
      • ITPR2_HUMAN antibody
      • Type 2 inositol 1 4 5 trisphosphate receptor antibody
      • Type 2 inositol 1 antibody
      • Type 2 inositol 145 trisphosphate receptor antibody
      • Type 2 InsP3 receptor antibody
      see all

    Anti-ITPR2 antibody images

    • Shows immunolocalization of IP3R-II in rat brain using ab5805.

    References for Anti-ITPR2 antibody (ab5805)

    This product has been referenced in:
    • Okamoto Y  et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . Read more (PubMed: 22285480) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"