The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 22285480
Application notesIs unsuitable for WB.
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Tissue specificityIsoform Short is found in skeletal muscle and heart.
Involvement in diseaseAnhidrosis, isolated, with normal sweat glands
Sequence similaritiesBelongs to the InsP3 receptor family. Contains 5 MIR domains.
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Post-translational modificationsPhosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Shows immunolocalization of IP3R-II in rat brain using ab5805.
References for Anti-ITPR2 antibody (ab5805)
This product has been referenced in:
Okamoto Y et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol52:988-97 (2012).
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