Overview

  • Product name
    ITPR2 peptide

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITPR2, catalog ab5805. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 4
    • 5-trisphosphate receptor
    • Inositol 1 4 5 trisphosphate receptor type 2
    • Inositol 1,4,5-trisphosphate receptor type 2
    • Inositol 145 trisphosphate receptor type 2
    • InsP3 R2
    • InsP3R2
    • IP3 R2
    • IP3 receptor
    • IP3 receptor isoform 2
    • IP3R 2
    • IP3R2
    • ITPR 2
    • Itpr2
    • ITPR2_HUMAN
    • Type 2 inositol 1
    • Type 2 inositol 1 4 5 trisphosphate receptor
    • Type 2 inositol 145 trisphosphate receptor
    • Type 2 InsP3 receptor
    see all
  • Function
    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • Tissue specificity
    Isoform Short is found in skeletal muscle and heart.
  • Involvement in disease
    Anhidrosis, isolated, with normal sweat glands
  • Sequence similarities
    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • Domain
    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt

References

ab5842 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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