Overview

  • Product nameAnti-ITPR3 antibody
    See all ITPR3 primary antibodies
  • Description
    Rabbit polyclonal to ITPR3
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Guinea pig, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 625-675 of Human ITPR3 (NP_002215.2).

  • Positive control
    • Human Breast Carcinoma, Colon Carcinoma, Osteosarcoma, Ovarian Carcinoma, and Stomach Adenocarcinoma tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab113292 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
  • Tissue specificityExpressed in intestinal crypt and villus epithelial cells.
  • Sequence similaritiesBelongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • 5-trisphosphate receptor type 3 antibody
    • FLJ36205 antibody
    • Inositol 1 antibody
    • Inositol 1,4,5 trisphosphate receptor type 3 antibody
    • InsP3R3 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 3 antibody
    • IP3R 3 antibody
    • IP3R antibody
    • IP3R3 antibody
    • ITPR 3 antibody
    • ITPR3 antibody
    • ITPR3_HUMAN antibody
    • Type 3 inositol 1 antibody
    • Type 3 inositol 1,4,5 trisphosphate receptor antibody
    • Type 3 InsP3 receptor antibody
    see all

Anti-ITPR3 antibody images

  • ab113292, at 1/250 dilution, staining ITPR3 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry with DAB staining.
  • ab113292, at 1/250 dilution, staining ITPR3 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1/100.

References for Anti-ITPR3 antibody (ab113292)

ab113292 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"