• Product nameAnti-JAB1 antibody [6C3]
    See all JAB1 primary antibodies
  • Description
    Mouse monoclonal [6C3] to JAB1
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Fusion protein encoding the full-length (amino-acids 1-334) mouse JAB-1 gene expressed in E. coli.

  • Positive control
    • Recombinant JAB-1 protein or 293 whole cell lysate.


Associated products


Our Abpromise guarantee covers the use of ab496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml.
IP Use a concentration of 0.5 - 1 µg/ml.


  • FunctionProbable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.
  • Sequence similaritiesBelongs to the peptidase M67A family. CSN5 subfamily.
    Contains 1 MPN (JAB/Mov34) domain.
  • DomainThe JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 38 kDa Mov34 homolog antibody
    • COP9 (constitutive photomorphogenic) homolog subunit 5 antibody
    • COP9 constitutive photomorphogenic homolog subunit 5 antibody
    • COP9 signalosome complex subunit 5 antibody
    • COP9 signalosome subunit 5 antibody
    • Cop9 subunit 5 antibody
    • COPS 5 antibody
    • cops5 antibody
    • CSN 5 antibody
    • CSN5 antibody
    • CSN5_HUMAN antibody
    • JAB 1 antibody
    • Jun activation domain binding protein 1 antibody
    • Jun activation domain binding protein antibody
    • Jun activation domain-binding protein 1 antibody
    • MGC3149 antibody
    • MOV 34 antibody
    • MOV34 antibody
    • MOV34 family, 38-KD member antibody
    • SGN 5 antibody
    • SGN5 antibody
    • Signalosome subunit 5 antibody
    see all

References for Anti-JAB1 antibody [6C3] (ab496)

This product has been referenced in:
  • Ferrandina G  et al. Survivin expression in ovarian cancer and its correlation with clinico-pathological, surgical and apoptosis-related parameters. Br J Cancer 92:271-7 (2005). Read more (PubMed: 15655541) »

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