Overview

  • Product nameAnti-Jagged 2 antibody
    See all Jagged 2 primary antibodies
  • Description
    Rabbit polyclonal to Jagged 2
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) at the C-terminal of last 50 aa of human Jagged 2 conjugated to KLH

  • Positive control
    • Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab60041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • RelevanceJagged 2 is a Notch ligand involved in the mediation of Notch signaling. Jagged 2 is expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged 2 is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for Jagged 2.
  • Cellular localizationCell Membrane
  • Database links
  • Alternative names
    • D12Ggc2e antibody
    • HJ 2 antibody
    • HJ2 antibody
    • JAG 2 antibody
    • JAG2 antibody
    • Jagged 2 precursor antibody
    • Jagged2 antibody
    • Protein jagged 2 antibody
    • SER2 antibody
    • Syndactylism antibody
    see all

Anti-Jagged 2 antibody images

  • ab60041 at 1/50-1/100 dilution staining Jagged 2 in Human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

References for Anti-Jagged 2 antibody (ab60041)

This product has been referenced in:
  • Pietras A  et al. JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation. Mol Cancer Res 9:626-36 (2011). WB, IHC-P ; Human . Read more (PubMed: 21402725) »
  • Jung SG  et al. Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma. Cancer Sci : (2010). IHC-P ; Human . Read more (PubMed: 20624166) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"