Overview

  • Product name
    Jingzhaotoxin-V
  • Description
    Potent TTX-R and TTX-S NaV channel blocker. Potent KV4.2 and KV4.3 channel blocker.
  • Biological description
    Potent TTX-R and TTX-S NaV channel blocker (IC50 values are 27.6 and 30.2 nM for TTX-R and TTX-S DRG neurons respectively). Potent KV4.2 and KV4.3 channel blocker (IC50 values are 52 and 425 nM for DRG transient outward potassium channels and KV4.3 respectively). Jingzhaotoxin-II (ab146041), Jingzhaotoxin-III (ab146042) and Jingzhaotoxin-XII (ab146040) are also available.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Luo J  et al. Molecular surface of JZTX-V (ß-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel) 6:2177-93 (2014). Read more (PubMed: 25055801) »
  • Cai LJ  et al. [Inhibition of Jingzhaotoxin-V on Kv4.3 channel]. Sheng Li Xue Bao 62:255-60 (2010). Read more (PubMed: 20571743) »
  • Zeng X  et al. Isolation and characterization of Jingzhaotoxin-V, a novel neurotoxin from the venom of the spider Chilobrachys jingzhao. Toxicon 49:388-99 (2007). Read more (PubMed: 17157888) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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