Overview

  • Product name
    Jingzhaotoxin-XII
  • Description
    Selective KV4.1 channel blocker
  • Biological description
    Selective KV4.1 channel blocker (IC50 = 363 nM). Modifies KV4.1 gating behavior. Phrixotoxin-1 (ab141844) analog. Jingzhaotoxin II (ab146041), Jingzhaotoxin-V (ab146039), and Jingzhaotoxin-III (ab146042) are also available.
  • Purity
    > 98%

Properties

  • Molecular weight
    3665.23
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C161H227N41O44S7
  • Sequence
    YCQKWMWTCDSERKCCEGYVCELWCKYNL (Modifications: C-terminal amide; Disulfide bonds: 2-16, 9-21, 15-25)
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in aqueous buffer
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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