Overview

  • Product name
    JIP1 peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Sequence
      GRKKRRQRRR-PP-RPKRPTTLNLFPQVPRSQD-amide

Specifications

Our Abpromise guarantee covers the use of ab52324 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Inhibition Assay

  • Form
    Liquid
  • Additional notes
    ab52324 is supplied at a concentration of 1mM in PBS.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

General Info

  • Alternative names
    • C jun amino terminal kinase interacting protein 1
    • C-jun-amino-terminal kinase-interacting protein 1
    • IB 1
    • IB-1
    • IB1
    • Islet brain 1
    • Islet-brain 1
    • JIP 1
    • JIP-1
    • JIP1_HUMAN
    • JNK interacting protein 1
    • JNK MAP kinase scaffold protein 1
    • JNK-interacting protein 1
    • MAPK8IP 1
    • MAPK8IP1
    • MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
    • Mitogen activated protein kinase 8 interacting protein 1
    • Mitogen-activated protein kinase 8-interacting protein 1
    • PRKM8
    • PRKM8 interacting protein
    • PRKM8IP
    see all
  • Relevance
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Tissue specificity: Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis. Disease: Diabetes mellitus, non-insulin-dependent Similarity: Belongs to the JIP scaffold family. Contains 1 PID domain. Contains 1 SH3 domain. Domain: The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway. A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun by MAPK8, MAPK9 and MAPK10. The SH3 domain mediates homodimerization. PTM: Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases. Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.
  • Cellular localization
    Cytoplasmic. Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus

References

ab52324 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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