The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesab52324 is supplied at a concentration of 1mM in PBS.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
C jun amino terminal kinase interacting protein 1
Islet brain 1
JNK interacting protein 1
JNK MAP kinase scaffold protein 1
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
Mitogen activated protein kinase 8 interacting protein 1
PRKM8 interacting protein
RelevanceThe JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module and is required for JNK activation in response to excitotoxic stress. Cytoplasmic JIP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. It may also participate in ApoER2-specific reelin signaling and directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. It appears to have a role in cell signaling in mature and developing nerve terminals and may function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It functions as an anti-apoptotic protein whose level seems to influence the beta-cell death or survival response.
Cellular localizationCytoplasmic. Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus
References for JIP1 peptide (ab52324)
has not yet been referenced specifically in any publications.
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