Overview

  • Product nameAnti-JMJD1C antibody
    See all JMJD1C primary antibodies
  • Description
    Rabbit polyclonal to JMJD1C
  • Specificityab106457 does not cross-react with JMJD1A or JMJD1B.
  • Tested applicationsSuitable for: ICC/IF, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 20 amino acid synthetic peptide from near the amino terminus of Human JMJD1C (NP_116165).

  • Positive control
    • WB: Human liver tissue lysate IHC-P: Rat liver tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab106457 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 285 kDa.

Target

  • FunctionProbable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
  • Sequence similaritiesBelongs to the JHDM2 histone demethylase family.
    Contains 1 JmjC domain.
  • DomainLeu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • JHD2C_HUMAN antibody
    • Jmjd1c antibody
    • Jumonji domain containing 1C antibody
    • Jumonji domain-containing protein 1C antibody
    • Probable JmjC domain-containing histone demethylation protein 2C antibody
    • Thryoid receptor interacting protein antibody
    • Thyroid receptor-interacting protein 8 antibody
    • TR-interacting protein 8 antibody
    • TRIP-8 antibody
    • TRIP8 antibody
    see all

Anti-JMJD1C antibody images

  • Immunofluorescence of JMJD1C in rat liver tissue with ab106457 at 20 ug/mL.

  • Lane 1 : Anti-JMJD1C antibody (ab106457) at 1 µg/ml
    Lane 2 : Anti-JMJD1C antibody (ab106457) at 2 µg/ml

    Lane 1 : Human liver tissue lysate
    Lane 2 : Human liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 285 kDa
  • ab106457, at 2.5 ug/ml, staining JMJD1C in rat liver tissue.

References for Anti-JMJD1C antibody (ab106457)

ab106457 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your interest in Abcam's JMJD1C antibodies. I have confirmed that for both antibodies, the immunogen sequences are conserved in both variants, therefore the antibodies will react with variant 1 and 2 of JMJD1C. I hope this information...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"