Biological descriptionHighly selective H4 receptor silent antagonist (Ki = 26 nM). Shows >540-fold selectivity over the H3 receptor (Ki = 14.1 µM). Orally active in vivo.
Chemical name(5-Chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone maleate
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for JNJ 10191584 maleate (VUF 6002) (ab120191)
This product has been referenced in:
Zhang M et al. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. Pharmacol Ther113:594-606 (2007).
Read more (PubMed: 17275092) »
Coruzzi G et al. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. Eur J Pharmacol563:240-4 (2007).
Read more (PubMed: 17382315) »
Terzioglu N et al. Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorg Med Chem Lett14:5251-6 (2004).
Read more (PubMed: 15454206) »