Overview

  • Product nameJNJ 10191584 maleate (VUF 6002)
  • Description
    Selective H4 antagonist
  • Alternative names
    • VUF 6002
  • Biological descriptionHighly selective H4 receptor silent antagonist (Ki = 26 nM). Shows >540-fold selectivity over the H3 receptor (Ki = 14.1 µM). Orally active in vivo.
  • Purity> 99%

Properties

    References for JNJ 10191584 maleate (VUF 6002) (ab120191)

    This product has been referenced in:
    • Zhang M  et al. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. Pharmacol Ther 113:594-606 (2007). Read more (PubMed: 17275092) »
    • Coruzzi G  et al. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. Eur J Pharmacol 563:240-4 (2007). Read more (PubMed: 17382315) »
    • Terzioglu N  et al. Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorg Med Chem Lett 14:5251-6 (2004). Read more (PubMed: 15454206) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"