Overview

  • Product nameJNJ 1661010
  • Description
    Potent, selective and reversible fatty acid amide hydrolase inhibitor
  • Biological descriptionPotent, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 12 nM). Displays >100-fold selectivity for FAAH-1 over FAAH-2. Active in vivo and brain permeable. Displays analgesic effects.
  • Purity> 99%

Properties

  • Chemical nameN-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
  • Molecular weight365.45
  • Chemical structureChemical Structure
  • Molecular formulaC19H19N5OS
  • CAS Number681136-29-8
  • PubChem identifier2809273
  • Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=C(Nc1ccccc1)N2CCN(CC2)c3nc(ns3)c4ccccc4
  • Source

    Synthetic

  • Research areas

    References for JNJ 1661010 (ab120999)

    This product has been referenced in:
    • Karbarz MJ  et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg 108:316-29 (2009). Read more (PubMed: 19095868) »

    See 0 Publications for this product

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