Potent, selective and reversible fatty acid amide hydrolase inhibitor
Biological descriptionPotent, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 12 nM). Displays >100-fold selectivity for FAAH-1 over FAAH-2. Active in vivo and brain permeable. Displays analgesic effects.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Karbarz MJ et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg108:316-29 (2009).
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