Overview

  • Product nameAnti-JPH1 antibody
    See all JPH1 primary antibodies
  • Description
    Mouse monoclonal to JPH1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: VADEQVTAIV NKPLMSKAPT KEAGAVVPQS KYSGRHHIPN PSNGELHSQY HGYYVKLNAP QHPPVDVEDG DGSSQSSSA, corresponding to amino acids 501-580 of Human JPH1

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionJunctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
    • Tissue specificityAbundantly expressed in skeletal muscle. Very low levels in heart.
    • Sequence similaritiesBelongs to the junctophilin family.
      Contains 7 MORN repeats.
    • DomainThe MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
    • Cellular localizationCell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp762L0313 antibody
      • JP 1 antibody
      • JP-1 antibody
      • JP1 antibody
      • JPH 1 antibody
      • JPH1 antibody
      • JPH1_HUMAN antibody
      • Junctophilin 1 antibody
      • Junctophilin type 1 antibody
      • Junctophilin type1 antibody
      • Junctophilin-1 antibody
      • Junctophilin1 antibody
      • Mitsugumin 72 antibody
      • Mitsugumin72 antibody
      see all

    Anti-JPH1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57425 JPH1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    References for Anti-JPH1 antibody (ab57425)

    ab57425 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57425.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"