• Product name
    Anti-JPH3 antibody
  • Description
    Rabbit polyclonal to JPH3
  • Tested applications
    Suitable for: ICC/IF, WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic 18 amino acid peptide near the carboxy terminus of human JPH3 (protein accession number: NP_065706)

  • Positive control
    • Daudi cell lysate



Our Abpromise guarantee covers the use of ab79063 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 81 kDa.
ELISA Use at an assay dependent dilution.


  • Function
    Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic reticulum. May play an active role in certain neurons involved in motor coordination.
  • Tissue specificity
    Specifically expressed in brain.
  • Involvement in disease
    Defects in JPH3 are the cause of Huntington disease-like type 2 (HDL2) [MIM:606438]. Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial adult onset chorea and subcortical dementia that usually begin during the fourth decade of life.
  • Sequence similarities
    Belongs to the junctophilin family.
    Contains 8 MORN repeats.
  • Domain
    The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • JP-3 antibody
    • JP3 antibody
    • JPH3 antibody
    • JPH3_HUMAN antibody
    • Junctophilin 3 antibody
    • Junctophilin type 3 antibody
    • Junctophilin-3 antibody
    • TNRC22 antibody
    • Trinucleotide repeat-containing gene 22 protein antibody
    see all


  • All lanes : Anti-JPH3 antibody (ab79063) at 1 µg/ml

    Lane 1 : Daudi cell lysate
    Lane 2 : Daudi cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size : 81 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)
  • Immunofluorescence of JPH3 in Human Brain cells using ab79063 at 20 ug/ml.


ab79063 has not yet been referenced specifically in any publications.

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