Overview

  • Product name
  • Description
    Mouse polyclonal to JTB
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Full length protein corresponding to Human JTB aa 1-146. (AAH00996).
    Sequence:

    MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSAL MEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI


    Database link: O76095

  • Positive control
    • JTB transfected 293T cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.2
    Constituent: 100% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab172673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa.

Target

  • Function
    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
  • Tissue specificity
    Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
  • Sequence similarities
    Belongs to the JTB family.
  • Cellular localization
    Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
  • Information by UniProt
  • Database links
  • Alternative names
    • hJT antibody
    • HJTB antibody
    • HSPC222 antibody
    • JTB antibody
    • JTB_HUMAN antibody
    • Jumping translocation breakpoint antibody
    • Jumping translocation breakpoint protein antibody
    • OTTHUMP00000034759 antibody
    • PAR antibody
    • PAR protein antibody
    • Prostate androgen regulated protein antibody
    • Prostate androgen-regulated protein antibody
    • Protein JTB antibody
    see all

Images

  • All lanes : Anti-JTB antibody (ab172673) at 1 µg/ml

    Lane 1 : JTB transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 16 kDa

References

ab172673 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab172673.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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