• Product nameAnti-Junctophilin-2 antibody
    See all Junctophilin-2 primary antibodies
  • Description
    Rabbit polyclonal to Junctophilin-2
  • SpecificityMultiple isoforms of JPH2 are known to exist.
  • Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A 17 amino acid peptide near the carboxy terminus of Human Junctophilin-2.

  • Positive control
    • Human Heart and Skeletal Muscle. Mouse brain tissue lysate.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab110056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 75 kDa.
IHC-P Use a concentration of 5 µg/ml.


  • FunctionContributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.
  • Tissue specificitySpecifically expressed in skeletal muscle and heart.
  • Involvement in diseaseDefects in JPH2 are the cause of cardiomyopathy familial hypertrophic type 17 (CMH17) [MIM:613873]. CMH17 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similaritiesBelongs to the junctophilin family.
    Contains 8 MORN repeats.
  • DomainThe MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • Cellular localizationCell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ40969 antibody
    • JP-2 antibody
    • JP2 antibody
    • Jph2 antibody
    • JPH2_HUMAN antibody
    • Junctophilin 2 antibody
    • Junctophilin type 2 antibody
    • Junctophilin-2 antibody
    • OTTHUMP00000031651 antibody
    • OTTHUMP00000031652 antibody
    see all

Anti-Junctophilin-2 antibody images

  • Lane 1 : Anti-Junctophilin-2 antibody (ab110056) at 1 µg/ml
    Lane 2 : Anti-Junctophilin-2 antibody (ab110056) at 2 µg/ml

    Lane 1 : Mouse brain tissue lysate
    Lane 2 : Mouse brain tissue lysate

    Predicted band size : 75 kDa
  • ab110056 at 5 µg/ml staining Junctophilin-2 in Formalin-Fixed, Paraffin-Embedded Human Heart by Immunohistochemistry.
  • ab110056 at 5 µg/ml staining Junctophilin-2 in Formalin-Fixed, Paraffin-Embedded Human Skeletal Muscle by Immunohistochemistry.

References for Anti-Junctophilin-2 antibody (ab110056)

ab110056 has not yet been referenced specifically in any publications.

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