Anti-Junctophilin-2 antibody (ab79071)


  • Product nameAnti-Junctophilin-2 antibody
    See all Junctophilin-2 primary antibodies
  • Description
    Rabbit polyclonal to Junctophilin-2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic 17 amino acid peptide near the carboxy terminus of human Junctophilin-2 (NP_065166)

  • Positive control
    • Mouse brain tissue lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesAffinity chromatography purified via peptide column
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products


Our Abpromise guarantee covers the use of ab79071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 74 kDa.Can be blocked with Junctophilin-2 peptide (ab110064).
ELISA Use at an assay dependent dilution.


  • FunctionContributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.
  • Tissue specificitySpecifically expressed in skeletal muscle and heart.
  • Involvement in diseaseDefects in JPH2 are the cause of cardiomyopathy familial hypertrophic type 17 (CMH17) [MIM:613873]. CMH17 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similaritiesBelongs to the junctophilin family.
    Contains 8 MORN repeats.
  • DomainThe MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • Cellular localizationCell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ40969 antibody
    • JP-2 antibody
    • JP2 antibody
    • Jph2 antibody
    • JPH2_HUMAN antibody
    • Junctophilin 2 antibody
    • Junctophilin type 2 antibody
    • Junctophilin-2 antibody
    • OTTHUMP00000031651 antibody
    • OTTHUMP00000031652 antibody
    see all

Anti-Junctophilin-2 antibody images

  • Lane 1 : Anti-Junctophilin-2 antibody (ab79071) at 1 µg/ml
    Lane 2 : Anti-Junctophilin-2 antibody (ab79071) at 2 µg/ml

    Lane 1 : mouse brain tissue lysate
    Lane 2 : mouse brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size : 74 kDa
    Observed band size : 74 kDa
    Additional bands at : 64 kDa (possible isoform).

References for Anti-Junctophilin-2 antibody (ab79071)

ab79071 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 10 µg
Gel Running Conditions Reduced Denaturing (8%)
Sample Sheep Tissue lysate - whole (Cardiac)
Specification Cardiac
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

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Submitted Nov 15 2013