Overview

  • Product name
  • Description
    Rabbit polyclonal to K0776
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, from a region within C-terminal amino acids 433-463 of Human K0776 (O94874)

  • Positive control
    • MCF7 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab103047 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 90 kDa.

Target

  • Function
    E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.
  • Tissue specificity
    Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC.
  • Sequence similarities
    Belongs to the UFL1 family.
  • Post-translational
    modifications
    Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
  • Cellular localization
    Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 UFM1-protein ligase 1 antibody
    • KIAA0776 antibody
    • LZAP-binding protein antibody
    • Maxer antibody
    • NLBP antibody
    • RCAD antibody
    • UFL1 antibody
    • UFL1_HUMAN antibody
    • UFM1 specific ligase 1 antibody
    see all

Images

  • Anti-K0776 antibody (ab103047) at 1/100 dilution + MCF7 cell lysate at 35 µg

    Predicted band size : 90 kDa

References

ab103047 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab103047.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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