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K252a

Product code: ab120419 (formerly Asc-419)

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Overview

Product name

K252a

Description

Highly potent inhibitor of protein and CAM kinases

Biological description

Highly potent, cell permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC50 = 18-25 nM), Serine/threonine protein kinases (IC50 values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analogue of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.

Purity

> 99%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

Molecular Weight

467.48

Chemical structure

Chemical Structure

Molecular formula

C27H21N3O5

CAS Number

99533-80-9

Solubility

Soluble in DMSO to 25 mM and in ethanol to 5 mM

Storage instructions

Store at -20°C (desiccating conditions).

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Kinase >> General >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> CAM Kinase
Biochemicals >> Chemical Type >> Biochemicals

References for K252a               (ab120419)

This product has been referenced in:

  • Pan J  et al. K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways. Mol Pharmacol 72:1607-18 (2007).Read more (PubMed: 17855652) »
  • Raychaudhuri SP  et al. K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. J Invest Dermatol 122:812-9 (2004).Read more (PubMed: 15086569) »

See all 4 publications for this product

Publishing research using ab120419? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"