Biological descriptionCell-permeable phytoestrogen and dietary flavonoid. Proapoptotic and protects against amyloid beta peptide neurotoxicity in vivo. Has many biological actions including: inhibition of topoisomerase-1, MAO COX, estrogenic effects and activation of the mitochondrial Ca2+ uniporter.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kim JK et al. Protective effects of kaempferol (3,4',5,7-tetrahydroxyflavone) against amyloid beta peptide (Abeta)-induced neurotoxicity in ICR mice. Biosci Biotechnol Biochem74:397-401 (2010).
Read more (PubMed: 20139605) »
Montero M et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem J384:19-24 (2004).
Read more (PubMed: 15324303) »
Sloley BD et al. Identification of kaempferol as a monoamine oxidase inhibitor and potential Neuroprotectant in extracts of Ginkgo biloba leaves. J Pharm Pharmacol52:451-9 (2000).
Read more (PubMed: 10813558) »