Overview

  • Product name
    Anti-Kallikrein 11 antibody
    See all Kallikrein 11 primary antibodies
  • Description
    Rabbit polyclonal to Kallikrein 11
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-275 of Human Kallikrein 11 (Q9UBX7).

  • Positive control
    • 293T, A431, H1299, HeLaS3, HepG2, MOLT4, Raji and Mouse brain whole cell lysates; Human Cal27 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab152098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 31 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • Tissue specificity
    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • Sequence similarities
    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
    • Alternative names
      • Hippostasin antibody
      • hK11 antibody
      • Kallikrein 11 antibody
      • Kallikrein 11 isoform 1 preproprotein antibody
      • Kallikrein 11 isoform 2 precursor antibody
      • Kallikrein 11 precursor antibody
      • Kallikrein related peptidase 11 antibody
      • Kallikrein-11 inactive chain 2 antibody
      • KLK 11 antibody
      • Klk11 antibody
      • KLK11_HUMAN antibody
      • MGC33060 antibody
      • Protease serine 20 trypsin like antibody
      • Protease serine trypsin like antibody
      • PRSS20 antibody
      • Serine protease 20 antibody
      • TLSP antibody
      • Trypsin like protease antibody
      • Trypsin-like protease antibody
      see all

    Images

    • Western blot - Anti-Kallikrein 11 antibody (ab152098)
      Western blot - Anti-Kallikrein 11 antibody (ab152098)
      Anti-Kallikrein 11 antibody (ab152098) at 1/2000 dilution + MOLT4 whole cell lysate at 30 µg

      Predicted band size: 31 kDa



      10% SDS PAGE
    • Western blot - Anti-Kallikrein 11 antibody (ab152098)
      Western blot - Anti-Kallikrein 11 antibody (ab152098)
      Anti-Kallikrein 11 antibody (ab152098) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

      Predicted band size: 31 kDa



      12% SDS PAGE
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (ab152098)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (ab152098)
      Immunohistochemical analysis of paraffin-embedded Human Cal27 xenograft tissue labeling Kallikrein 11 with ab152098 at 1/100 dilution.

    References

    ab152098 has not yet been referenced specifically in any publications.

    Publishing research using ab152098? Please let us know so that we can cite the reference in this datasheet.

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