Overview

  • Product name
    Anti-Kallikrein 11 antibody
    See all Kallikrein 11 primary antibodies
  • Description
    Rabbit polyclonal to Kallikrein 11
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-275 of Human Kallikrein 11 (Q9UBX7).

  • Positive control
    • 293T, A431, H1299, HeLaS3, HepG2, MOLT4, Raji and Mouse brain whole cell lysates; Human Cal27 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab152098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 31 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • Tissue specificity
    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • Sequence similarities
    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Hippostasin antibody
    • hK11 antibody
    • Kallikrein 11 antibody
    • Kallikrein 11 isoform 1 preproprotein antibody
    • Kallikrein 11 isoform 2 precursor antibody
    • Kallikrein 11 precursor antibody
    • Kallikrein related peptidase 11 antibody
    • Kallikrein-11 inactive chain 2 antibody
    • KLK 11 antibody
    • Klk11 antibody
    • KLK11_HUMAN antibody
    • MGC33060 antibody
    • Protease serine 20 trypsin like antibody
    • Protease serine trypsin like antibody
    • PRSS20 antibody
    • Serine protease 20 antibody
    • TLSP antibody
    • Trypsin like protease antibody
    • Trypsin-like protease antibody
    see all

Images

  • Anti-Kallikrein 11 antibody (ab152098) at 1/2000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 31 kDa
  • Anti-Kallikrein 11 antibody (ab152098) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size : 31 kDa
  • Immunohistochemical analysis of paraffin-embedded Human Cal27 xenograft tissue labeling Kallikrein 11 with ab152098 at 1/100 dilution.

References

ab152098 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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