Overview

  • Product nameAnti-Kallikrein 12 antibody
    See all Kallikrein 12 primary antibodies
  • Description
    Rabbit polyclonal to Kallikrein 12
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 84-113 of Human Kallikrein 12 (NP_062544.1, NP_665901.1).

  • Positive control
    • WiDr cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab124089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 27 kDa.

Target

  • RelevanceThe human tissue Kallikrein gene family encodes 15 serine proteases. All Kallikreins share structural similarities including cysteine residues, a catalytic triad of His, Asp, and Ser residues, typically five coding exons, and varied intron phases. Kallikreins are predominantly secreted as inactive zymogens prior to activation by cleavage of an N-terminal peptide, and all function extracellularly. Kallikreins can be activated autocatalytically, via other Kallikreins, or additional proteases. While structurally similar, Kallikrein family members have distinct functions and have key roles in many physiological and pathological processes. Many human tissue Kallikreins also show promise as cancer biomarkers, which may facilitate earlier detection and characterization of many forms of cancer. Kallikrein 12, also known as Kallikrein-like5 (KLK-L5), is a trypsin-like serine proteinase. It was discovered by cloning the kallikrein locus on chromosome 19, and was found to be similar to the other kallikrein family genes. It is produced by a number of tissues, including pancreas, salivary gland, breast, prostate, uterus, lung, thymus, thyroid, brain, stomach and colon. Kallikrein 12 message has been reported to be decreased in breast cancer. Different splice variants of kallikrein-12 have been identified; a 254 amino acid form, 248 amino acids form, and a truncated 111 amino acid form.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • DKFZp686H1078 antibody
    • Kallikrein like protein 5 antibody
    • Kallikrein related peptidase 12 antibody
    • Kallikrein12 antibody
    • KLK 12 antibody
    • KLK L5 antibody
    • KLK12 antibody
    • KLKL5 antibody
    • MGC42603 antibody
    see all

Anti-Kallikrein 12 antibody images

  • Anti-Kallikrein 12 antibody (ab124089) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 27 kDa

References for Anti-Kallikrein 12 antibody (ab124089)

ab124089 has not yet been referenced specifically in any publications.

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