Kallikrein 2 antibody - Kallikrein loop (ab28294)

Product Name 

Kallikrein 2 antibody - Kallikrein loop

Product type 

Primary antibodies

Description 

Rabbit polyclonal to Kallikrein 2 - Kallikrein loop

Immunogen 

This antibody is made to a synthetic peptide based on the Kallikrein loop area of human Kallikrein 2.(Peptide available as ab41420.)

Reacts with 
(species key)

Hu

Specificity 

Ab28294 reacts with Kallikrein 2, and does not react with the kallikreins (hK1, 3-15).

We have a range of domain specific antibodies for this target. For a full list please see all Kallikrein 2 antibodies

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: Use at an assay dependent dilution. Predicted molecular weight: 29 kDa. A recommended starting concentration for Western blots is 1/1,000 when using colorimetric substrates such as BCIP/NBT and 1/5,000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Kallikreins
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Kallikreins

Relevance 

Kallikreins (KLKs) are a subgroup of trypsin-like serine proteases and are implicated in carcinogenesis. Kallikrein 2 is most closely related to Kallikrein 3 (PSA), with 78% identity and with kallikrein 1, at 68% identity. Like Kallikrein 3, Kallikrein 2 is found in greatest abundance in the prostate, but at much lower levels than Kallikrein 3. In addition, Kallikrein 2 seems to be more labile than Kallikrein 1 or Kallikrein 3 and is often found in a cleaved form. Kallikrein 2 is inhibited by Protein C Inhibitor (PCI).

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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